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In any case, we examined EAAC1 KO mice before 3 months old when no neurodegeneration was observed in the brain

Peroxyl radicals (ROO), generated through controlled thermal decomposition of 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) at physiological temperature (37 C), oxidize a fluorescent probe (e.g., fluorescein)

While Grn homozygous null ( Grn / ) mice are viable and fertile, they exhibit several features of FTLD- GRN and CLN11 including lysosomal dysregulation, lipofuscinosis, neuroinflammation, synaptic loss, retinal ganglion cell (RGC) loss, and obsessive compulsive disorder (OCD)-like behavior as well as social deficits [16, 88, 137, 174,175,176,177] and therefore have been widely used as a model of FTLD- GRN and CLN11

[DOI] [PubMed] [Google Scholar] 27.Balazy M., Kaminski P.M., Mao K., Tan J., Wolin M.S

ALT activation is more commonly observed in immortalized or transformed MSCs lacking detectable telomerase activity

Jan 2015;40(1):17-22